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Loyal's Celine Halioua: From Defying Doubters To Pioneering Dog Longevity

Episode 2 of 'The Upstarts Podcast' dives into Celine's Upstart Moment in building a category-creating startup that helps our dogs live longer.

Alex Konrad's avatar
Alex Konrad
Feb 19, 2026
∙ Paid

When Loyal founder Celine Halioua told people she was building a dog longevity startup, they laughed in her face.

Now she’s running what could be the largest-ever clinical trial to extend canine lifespans — pursuing FDA approval for multiple drugs to help senior and large dogs live two years longer or more.

On our latest episode of The Upstarts Podcast, Celine shares her unusual journey to raising $250 million for a startup that defies easy labels, her Upstart Moment taking her biggest fear head-on, and the example she hopes to set for another generation of women deep tech founders.

Chapters:
0:00 Intro to Celine and Loyal
1:42 Celine’s origins in human longevity
12:44 Breaking Silicon Valley patterns
14:51 The largest clinical trial for pets
18:13 Handling founder highs and lows
20:53 Celine’s Upstart Moment
24:53 Overcoming her biggest fear
30:56 Finding the right people
34:29 Loyal’s healthier future
35:23 Setting a new example


If you enjoy the episode, please consider giving us a nice review and comment wherever you watch/listen – and share it with a friend! It makes a huge difference and will help this show reach the audience we hope you agree it deserves.

A big thanks to Mercury, our presenting sponsor this season.

  • Listen on Apple Podcasts

  • Listen on Spotify

For paid subscribers, we break down our three favorite takeaways below, including a couple of lessons every startup should keep in mind.

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